ヒト白血病細胞の分化・増殖・細胞死を制御する分子機構の解明

  1. Kasukabe T, Okabe-Kado J, Kato N, Honma Y, Kumakura S. Cotylenin A and arsenic trioxide cooperatively suppress cell proliferation and cell invasion activity in human breast cancer cells. Int J Oncol  2015;46 :841-8
  2. Mishima S, Nagai A, Abdullah S, Matsuda C, Taketani T, Kumakura S, Shibata H, Ishikura H, Kim SU, Masuda J. Effective ex vivo expansion of hematopoietic stem cells using osteoblast-differentiated mesenchymal stem cells is CXCL12 dependent. Eur J Haematol 84: 538-46, 2010
  3. Kumakura S, Ishikura H. TNF signaling cascades. Cell death and survival. In: Cater R. Kettleworth, Editors. Cell Apoptosis Research Advances. Nova Science Publishers, Inc. New York; pp.291-319 2007
  4. Nakashima A, Kumakura S, Mishima S, Ishikura H, Kobayashi S. IFN- enhances TNF--induced apoptosis through down-regulation of c-Myc protein expression in HL-60 cells. J Exp Clin Cancer Res 24: 447-56, 2005
  5. Kumakura S, Ishikura H, Maniwa Y, Munemasa S, Tsumura H, Masuda J, Kobayashi S. Activation of protein kinase C enhances TNF--induced differentiation by preventing apoptosis via rapid up-regulation of c-myc protein expression in HL-60 cells. Leuk Lymphoma 43: 497-503, 2003
  6. Kumakura S, Ishikura H, Tsumura H, Kobayashi S. Phagocytosis of terminally differentiated acute promyelocytic leukemia cells by marrow histiocytes during treatment with all-trans retinoic acid. Leuk Lymphoma 44: 2147-50, 2003
  7. Kumakura S, Ishikura H, Takahashi T, Maniwa Y, Munemasa S, Tsumura H, Kobayashi S. Regulation of bcl-2 protein expression by c-myc protein in HL-60 cells during the induction of differentiation-associated apoptosis. Shimane J Med Sci 20: 9-11, 2002
  8. Kumakura S, Ishikura H, Tsumura H, Nakashima A, Sato Y, Kobayashi S. Cell cycle-independent down-regulation of bcl-2 protein expression in differentiating HL-60 cells. Leuk Lymphoma 36: 375-82, 2000
  9. Kumakura S, Ishikura H, Tsumura H, Nakashima A, Sato Y, Kobayashi S. Down-regulation of c-myc protein expression in G0/G1 phase of the cell cycle during the induction of differentiation by 1, 25 dihydroxyvitamin D3 in HL-60 cells. Shimane J Med Sci 16: 45-49, 1998
  10. Kumakura S, Ishikura H, Tsumura H, Nakashima A, Munemasa S, Sato Y, Kobayashi S. Differentiation induction of acute promyelocytic leukemia cells toward monocytic/macrophagic lineage. Shimane J Med Sci 16: 37-39, 1998
  11. Kumakura S, Ishikura H, Tsumura H, Iwata Y, Endo J, Kobayashi S. C-Myc and Bcl-2 protein expression during the induction of apoptosis and differentiation in TNF-treated HL-60 cells. Leuk Lymphoma 23: 383-394, 1996
  12. Kumakura S, Ishikura H, Tsumura H, Hayashi H, Endo J, Tsunematsu T. c-myc protein expression during cell cycle phases in differentiating HL-60 cells. Leuk Lymphoma 14: 171-180, 1994 Other
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